I have not tried the play with friends but enjoy playing versus the computer ‘bots’ (it is 4 handed because of the demands of showing all those cards on screen. Jokers can be anything, and I promise this game will capture your attention and you will be loving the genius programming that made it possible! Great way to practice your skills for when you are playing ‘for real’ with friends or relatives. Best of all, each round features simple graphics showing you what is required to lay down your cards! A set is three of a kind (any suit) and a run is 4 sequential cards of the same suit. The graphics are stellar, navigation was almost instantly intuitive, and you are able to configure several settings in the setup screen. I was incredibly happy to find this wonderful game on the Apple App Store today and immediately loaded it up on my iPad 12.9.